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Talisman is a quest item found by Geralt during the quest Family Matters in The Witcher 3: Wild Hunt. Geralt finds the talisman by following the smell of wine from a broken bottle to one of the landings on the stairs where the talisman is hidden beneath a floor board.
"Freshly cut spruce sprinkled with goat's blood, then tempered with an incense of earthsmoke and juniper. For Anna. To protect her."
Pellar

This talisman was created by the Pellar for Anna Strenger, wife of Philip Strenger (the Bloody Baron), to protect her from "evil magics".