Witchers know hundreds of ways of fighting monsters. When tackling the queen of a kikimore swarm, only one method is effective — run like the wind. This tactic makes it hard to kill the beast, but it does ensure survival, which is a kind of victory.
The Queen cannot be fought properly, as it will inevitably kill Geralt in a single hit since the player is meant to escape, so don't waste time drinking potions for a boss fight. The player must instead run away from the Queen and use the Aard sign to first collapse the passage to slow down the queen and then use it to destroy the supports of the Salamandra Cave, which will bring down the section on top of the Kikimore and cause its death. You can then retrieve the Professor's remains and acquire the Kikimore Queen's nerve that can be used to make the Kikimore's Ire potion.Be careful when breaking the tunnel supports, standing too close will cause the rocks to collapse on top of you and kill you.
|Video: how to kill Kikimore queen on any difficulty|
- "Some scientists claim that kikimores behave like ants. They are divided into industrious workers and protective warriors. Life in a kikimore colony is centered around a great, unceasingly procreating female. The landscape around the queen's nest looks like a desert, littered with the remains of unfortunate creatures which unwisely lingered in the area. Not even birdsong can be heard."