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Unusual severed hand is a quest item in the Blood and Wine expansion. During the main quest, The Beast of Toussaint, it's found next to Louis de la Croix's body in Corvo Bianco's cellar.
The hand once belonged to The Beast of Beauclair but was important enough that he later sent a bruxa to recover it for him, possibly to destroy it. Geralt however, recovered it and later showed it to Regis who, with some help from the witcher, was able to brew Resonance: a concoction that would let the drinker glimpse into the hand owner's recent past events. Afterwards, Regis properly destroyed the hand as dictated by vampire custom.
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